@@@@ Nuclear power is one of energy resources that China will vigorously develop for a long term from now on. The issue of nuclear power security guarantee is a key to ensure the smooth implementation and the safe operation of the nuclear power plant construction. However,because of the vast territory of China,the great differences in geological conditions and the complex natural conditions of ocean,as well as a wide range of seis-mic activity,high strength and high frequency of earthquakes in China,nuclear power buildings based on cur-rent standardized design methods are facing problems. Moreover,the lessons of the 2011 Fukushima nuclear ac-cident due to destructive earthquake come out new problems to Chinese seismic safety of nuclear power engineer-ing. In this paper,by combining engineering practice in recent years of nuclear power engineering seismic safety evaluation of the Dalian University of Technology,the key issues and the research methods in the structural seis-mic safety of Chinese nuclear power projects and some progress made by the Dalian University of Technology in the study of“the function failure mechanism and seismic safety evaluation of the nuclear power plant engineer-ing structures under earthquake”are introduced. It mainly includes the method and strategy to analyze the founda-tional seismic adaptability of nuclear power plant,and seismic safety evaluation on water supply and drainage structures of nuclear power plant and seismic resistance and disaster prevention researches on engineering struc-tures related to nuclear safety.