学术论文

      坤泰胶囊联合雌性激素替代疗法治疗更年期综合征的临床效果及可能的作用机制

      Clinical effect and possible mechanism of Kuntai capsule and hormone replacement therapy in the treatment of climacteric syndrome

      摘要:
      目的:探讨坤泰胶囊联合雌性激素替代疗法治疗更年期综合征的临床效果及可能的作用机制.方法:选取我院收治的更年期综合征患者106例为研究对象,随机分为对照组和观察组患者各53例.对照组患者给予雌激素替代疗法,观察组患者则联合给予坤泰胶囊口服,两组均连续治疗12周.对比两组治疗的有效率,监测治疗前后患者激素水平,用Kupperman评分对主要更年期症状进行评价.结果:对照组有效率79.2%明显低于观察组患者的94.3%,差异性显著(P<0.05);观察组促卵泡生成素(FSH)、促黄体生成素(LH)水平显著低于对照组,而雌二醇(E2)水平则显著升高,差异性显著(P<0.05);经治疗后观察组患者的Kupperman评分显著低于对照组,差异性显著(P<0.05).结论:坤泰胶囊联合雌激素替代疗法利于缓解更年期综合征患者的临床症状,其机制与激发卵巢储备、提高卵巢功能及调控激素水平有一定相关性,值得临床深入研究.
      Abstract:
      Objectives:To explore the clinical effect and possible mechanism of Kuntai capsule and hormone replacement therapy in the treatment of climacteric syndrome.Methods:106 patients were randomly divided into control group and observation group,with 53 cases in each group.Patients in the control group were given hormone replacement therapy,while the patients in observation group were given Kuntai capsule on the basis of hormone replacement therapy,both for 12 weeks of treatment.The curative effect,levels of hormone,and the living quality with Kupperman scores were evaluated.Results:The efficiency in observation group was 94.3%,which was higher than that of control group (79.2%),with significant difference (P <0.05).The levels of FSH and LH in observation group were lower than these in control group,with significant difference (P < 0.05).The level of E2 in observation group were higher than that in control group after treatment (P < 0.05).The Kupperman score in observation group was lower than that in control group,with significant difference (P < 0.05).Conclusion:Treating climacteric syndrome with Kuntai capsule and hormone replacement therapy is good to improve the patients' clinical symptoms,worthy of clinical promotion.The mechanism may be associated with stimulating the ovarian reserve,improving ovarian function and regulating the levels of hormone.
      作者: 杨波 [1] 徐慧敏 [1] 朱亚芹 [1] 王家俊 [2] 刘开颜 [3]
      Author: YANG Bo [1] XU Huimin [1] ZHU Yaqin [1] WANG Jiajun [2] LIU Kaiyan [3]
      作者单位: 无锡市惠山区第二人民医院妇产科,江苏无锡,214187 无锡市妇幼保健院妇科,江苏无锡,214023 南通市第三人民医院妇产科,江苏南通,226006
      刊 名: 中国性科学 ISTIC
      年,卷(期): 2017, 26(11)
      分类号: R588.6
      在线出版日期: 2017年12月22日
      基金项目: 江苏省卫计委妇幼保健重点项目