学术论文

      派特灵外涂联合光动力疗法治疗阴茎尖锐湿疣的疗效及对患者局部HPV病毒载量水平的影响

      Effect of paiteling combined with photodynamic therapy on penile condyloma acuminatum and local HPV load level

      摘要:
      目的:探讨派特灵外涂联合光动力疗法治疗阴茎尖锐湿疣(CA)的疗效及对患者局部HPV病毒载量水平的影响.方法:抽取2013年6月至2016年10月我院68例阴茎尖锐湿疣患者,根据治疗方案分组,各34例.对照组行单纯光动力治疗,观察组在此基础上联合派特灵外涂治疗.统计两组临床疗效,并对比治疗前后患者局部人类乳头瘤病毒(HPV)载量、负性情绪[焦虑(HAMA)、抑郁(HAMD)]评分及生活质量评分.结果:(1)临床疗效:观察组治疗总有效率94.12% (32/34)高于对照组的76.47%(26/34),差异有统计学意义(P<0.05);(2) HPV病毒载量:治疗前,两组HPV病毒载量差异无统计学意义(P>0.05),经治疗,两组HPV病毒载量均有所减少,但观察组变化幅度大于对照组,差异有统计学意义(P<0.05);(3)负性情绪:治疗前,两组HAMA、HAMD评分差异无统计学意义(P>0.05),经治疗,观察组HAMA、HAMD评分低于对照组,差异有统计学意义(P<0.05);(4)生活质量:治疗前,两组生活质量评分差异无统计学意义(P>0.05),经治疗,观察组生活质量评分高于对照组,差异有统计学意义(P<0.05).结论:给予阴茎尖锐湿疣派特灵外涂联合光动力治疗,可有效降低患者局部HPV病毒载量,取得显著临床疗效,进而有利于患者负性情绪消除及生活质量的改善.
      Abstract:
      Objectives:To investigate the effect of paiteling combined with photodynamic therapy on penile condyloma acuminatum (CA) and its effect on local HPV viral load.Methods:68 penile CA patients in our hospital from June 2013 to October 2016 were divided into observation group and control group,with 34 cases in each group.The control group was treated with photodynamic therapy alone,and the observation group was treated with paiteling combined with photodynamic therapy.The clinical efficacy of two groups was statistically analyzed,and the local human papillomavirus (HPV) load,negative emotion [Hamilton anxiety (HAMA),Hamilton Depression Scale (HAMD)] score and quality of life score were compared before and after treatment.Results:(1) Clinical efficacy:The total effective rate was 94.12% (32/34) in observation group,which was higher than that in control group (76.47%,26/34) (P < 0.05).(2) HPV viral load:before treatment,HPV viral load of two groups was not statistically significant (P > 0.05).After treatment,HPV viral loads of two groups were reduced,but the observation group was significantly higher than control group,and the difference was statistically significant (P < 0.05).(3) Negative emotion:before treatment,there was no significant difference in HAMA and HAMD scores between two groups (P > 0.05).After treatment,the scores of HAMA and HAMD in observation group were lower than those in control group,and the difference was statistically significant (P < 0.05);(4) Quality of life:Before treatment,the difference of quality of life between two groups was not statistically significant (P > 0.05).After treatment,the quality of life in observation group was higher than that in control group,and the difference was statistically significant (P < 0.05).Conclusion:Paiteling combined with photodynarnic therapy can effectively reduce the local HPV viral load,and achieve significant clinical efficacy,which is conducive to the elimination of negative emotions and improvement of quality of life.
      作者: 张超 [1] 伍洲炜 [2] 施伟民 [3]
      Author: ZHANG Chao [1] WU Zhouwei [2] SHI Weimin [3]
      作者单位: 南京医科大学,南京210029;上海市松江区九亭医院皮肤科,上海201615 上海市第一人民医院皮肤科,上海,200080 南京医科大学,南京210029;上海市第一人民医院皮肤科,上海200080
      刊 名: 中国性科学 ISTIC
      年,卷(期): 2017, 26(11)
      分类号: R752.5+3
      在线出版日期: 2017年12月22日
      基金项目: 上海市松江区区科委课题