学术论文

      盐酸舍曲林联合中药伊木萨克治疗原发性早泄的临床研究

      Observation on the effect of sertraline combined with Yi Mu Sa Ke treating premature ejaculation

      摘要:
      目的:探讨盐酸舍曲林联合中成药伊木萨克治疗原发性早泄的临床疗效.方法:2013年6月至2015年10月门诊收集无器质性疾病的原发性早泄患者192例,年龄22~ 48岁,平均(27.63±6.78)岁,随机分成两组:A组患者单用盐酸舍曲林50mg/d,性生活前4~ 6h服用;B组患者服用盐酸舍曲林50mg/d,同时给予中成药伊木萨克,3片/d,睡前口服;连续服用4周,比较两组之间治疗有效率、治疗前后平均阴道内射精潜伏时间(IELT)和配偶性交满意度以及治疗期间的不良反应.结果:两组患者IELT在治疗后均显著延长,配偶性交满意度显著提高,而B组较A组增加更显著,存在明显的统计学差异(P<0.05).结论:盐酸舍曲林联合中成药伊木萨克治疗原发性早泄疗效显著优于单用盐酸舍曲林,但长期效果亟待进一步观察.
      Abstract:
      Objectives:To observe the effect of sertraline and Yi Mu Sa Ke in the treatment of premature ejaculation (PE).Methods:192 cases of PE were selected in clinic of andrology and randomly divided into group A and group B.Group A was treated with 50mg sertraline daily for 4 weeks,while group B was given 50mg sertratine daily plus three tablets of Yi Mu Sa Ke for 4 weeks.Before and after the treatment,the mean intravaginal ejaculation latency time (IELT),the intercourse satisfaction and the drug-related side effects were evaluated.Results:After the treatment,the IELT and the intercourse satisfaction in two groups increased.Group B was enhanced more significantly than group A (P < 0.05).Conclusion:Effects of sertraline and Yi Mu Sa Ke in the treatment of premature ejaculation are more effective than sertraline alone.Yet its longer efficacy studies are required to be evaluated.
      作者: 梁国庆 [1] 刘鹏 [1] 陈伟杰 [2] 韩文均 [1] 倪晨 [1] 孙建明 [1]
      Author: LIANG Guoqing [1] LIU Peng [1] CHEN Weijie [2] HAN Wenjun [1] NI Chen [1] SUN Jianming [1]
      作者单位: 上海中医药大学附属第七人民医院男性病科,上海,200137 上海中医药大学附属市中医医院泌尿外科,上海,200071
      刊 名: 中国性科学 ISTIC
      年,卷(期): 2017, 26(11)
      分类号: R698
      在线出版日期: 2017年12月22日
      基金项目: 上海市浦东新区名中医及名中医工作室建设项目,上海中医药大学附属第七人民医院人才培养计划