学术论文

      不同滴度的妊娠梅毒患者的治疗结局分析

      Treatment outcome of patients with different titers of pregnant syphilis

      摘要:
      目的:探讨不同滴度的妊娠梅毒治疗后对治疗结局的分析.方法:回顾性分析2014年1月至2016年9月于我科治疗的120名妊娠梅毒患者作为本次试验的研究对象.将选取的120名妊娠梅毒患者根据妊娠梅毒确诊时的甲苯胺红不加热血清试验(TRUST滴度)的不同分为三组:分别为妊娠梅毒确诊时TRUST滴度小于1∶4、妊娠梅毒确诊时TRUST滴度1∶4~1∶8、妊娠梅毒确诊时TRUST滴度1∶8以上.TRUST滴度小于1∶4组患者30例,TRUST滴度1∶4~1∶8组患者50例,TRUST滴度1∶8以上组患者40例.然后对各组患者的妊娠结局进行统计学分析.结果:TRUST滴度<1∶4组自然流产1例(3.3%)、宫内死胎1例(3.3%)、早产儿2例(6.7%)、新生儿先天性梅毒1例(3.3%),不良妊娠结局的发生率为16.7%;TRUST滴度1∶4~1∶8组自然流产5例(10%)、宫内死胎3例(6%)、早产儿5例(10%)、新生儿先天性梅毒5例(10%),不良妊娠结局的发生率为36%;TRUST滴度>1∶8组自然流产5例(12.5%)、宫内死胎4例(10%)、早产儿8例(20%)、新生儿先天性梅毒7例(17.5%),不良妊娠结局的发生率为60%.结论:妊娠梅毒不同滴度的患者治疗结局不同,妊娠梅毒滴度越高不良妊娠结局的发生率越高.
      Abstract:
      Objectives:To study the treatment outcome of patients with different titers of pregnant syphilis.Methods:A retrospective analysis on 120 pregnant patients with syphilis treated in our department from January 2014 to September 2016 was done.According to the TRUST titer,they were divided into three groups:TRUST titer less than 1 ∶ 4 (30 cases),TRUST titer 1 ∶ 4-1 ∶ 8 (50 cases) and TRUST titer more than 8 (40 cases).Then pregnancy outcome of each patient was statistically analyzed.Results:In TRUST drops < 1 ∶ 4 group,there were 1 case of natural abortion (3.3%),1 case of intrauterine demise (3.3%),2 cases of premature infants (6.7%)and 1 case of neonatal congenital syphilis (3.3%).The incidence of adverse pregnancy outcomes was 16.7%.In TRUST titer 1 ∶ 4-8 group,there were 5 cases of spontaneous abortion (10%),3 cases of intrauterine demise (6%),5 cases of premature infants (10%) and 5 cases of neonatal congenital syphilis (10%),and the incidence of adverse pregnancy outcomes was 36%.In TRUST titer > 8 group,there were 5 cases of spontaneous abortion (12.5%),4 cases of intrauterine demise (10%),8 cases of premature (20%) and 7 cases of neonatal congenital syphilis in (17.5%),and the incidence of adverse pregnancy outcomes was 60%.Conclusion:The higher the titer of syphilis in pregnant patients is,the higher incidence of adverse pregnancy outcome is.
      作者: 戴红艳 [1] 王昊珏 [1] 徐燕 [2]
      Author: DAI Hongyan [1] WANG Haojue [1] XU Yan [2]
      作者单位: 无锡市锡山人民医院妇产科,江苏无锡,214011 张家港市第三人民医院妇产科,江苏苏州,215611
      刊 名: 中国性科学 ISTIC
      年,卷(期): 2017, 26(11)
      分类号: R759.1
      在线出版日期: 2017年12月22日
      基金项目: 江苏省无锡市科技发展指导性计划(医疗卫生)项目