学术论文

      抗高血压药对单纯舒张期高血压短期降压疗效的对比研究

      Short-term curative effect of anti-hypertensive drugs on isolated diastolic hypertension

      摘要:
      目的比较不同类高血压药物在未治疗的单纯舒张期高血压患者中的短期疗效。方法纳入初发单纯舒张期高血压患者104例,年龄40岁~75岁,随机分为四个药物治疗组:①双氢克尿噻组(n=37):予双氢克尿噻(12.5~25)mg/d;②阿替洛尔组(n=19):予阿替洛尔(12.5~25)mg/d;③硝苯地平缓释片组(n=27):予硝苯地平缓释片(20~40)mg/d;④卡托普利组(n=21):予卡托普利(25~50)mg/d。比较干预4周后的治疗效果差异。结果治疗4周后所有患者舒张压均有明显下降(P<0.001),校正年龄、性别、体质指数、腰围、腰臀比、治疗前相应的血压值、血脂、血糖、吸烟、饮酒等传统危险因素后,四组间无统计学差异,但双氢克尿噻和硝苯地平较阿替洛尔和卡托普利降低收缩压的作用更明显(P<0.05)。结论阿替洛尔和卡托普利对收缩压影响较小,更适合单纯舒张期高血压患者的降压治疗。
      Abstract:
      Objective To compare the short-term curative effect of different anti-hypertensive drugs in the untreated patients with isolated diastolic hypertension. Methods The patients (n=104, aged from 40 to 75) with isolated diastolic hypertension for the first time were chosen, and then divided into four groups:hydrochlorothiazide group (n=37,12.5 mg/d-25 mg/d), atenolol group (n=19, 12.5 mg/d-25 mg/d), nifedipine group (n=27, 20 mg/d-40 mg/d) and captopril group (n=21, 25 mg/d-50 mg/d). The curative effect was compared after four weeks. Results The diastolic blood pressure was significantly decreased in all patients after treatment for four weeks. After adjusting age, sex, body mass index, waistline and waist-hip ratio, and relative blood pressure, blood fat, blood sugar, smoking and drinking before treatment, there was no statistical difference among four groups. But hydrochlorothiazide and nifedipine had more significant effect of reducing diastolic blood pressure compared with atenolol (P=0.040) and captopril (P=0.016). Conclusion Atenolol and captopril have less effects on diastolic blood pressure, so they are more suitable for the patients with isolated diastolic hypertension.
      作者: 韩运峰 [1] 王颖琦 [1] 樊晓寒 [2]
      Author: HAN Yun-feng [1] WANG Ying-qi [1] FAN Xiao-han [2]
      作者单位: 北京军区总医院干四科, 北京,100700 中国医学科学院
      年,卷(期): 2013, (4)
      分类号: R544.1
      机标分类号: R5 R97
      在线出版日期: 2013年9月23日
      基金项目: 863国家科技攻关计划,科技报社会公益基金专项研究