学术论文

      血浆miR-30a对老年急性心肌梗死患者的诊断价值研究

      Diagnostic value of plasma miR-30a in elderly patients with acute myocardial infarction

      摘要:
      目的 研究血浆中miR-30a对老年急性心肌梗死(AMI)患者的临床诊断价值.方法 随机选取2016年2月~2017年2月于湖北武汉市第八医院和湖北武汉市中医院进行治疗的58例老年急性心肌梗死患者和46例老年健康体检人群作为研究对象,实时荧光定量检测两组研究人群血浆miR-30a的相对表达量,ROC曲线法分析miR-30a诊断老年AMI诊断价值.结果 与健康老年人相比,老年AMI患者血清miR-30a明显升高[(0.08±0.04) vs. (0.16±0.06)],P<0.05;Pearson法分析显示,miR-30a相对表达量与血清肌酸激酶同工酶(CK-MB)(r=0.721,P<0.05)和cTnI(r=0.698,P<0.05)呈正相关;ROC曲线显示,miR-30a诊断老年AMI的敏感度为84.2%,特异度为69.6%.结论 miR-30a在老年急性心肌梗死患者血清中呈现高表达,并对老年急性心肌梗死具有一定的诊断价值.
      Abstract:
      Objective To study the diagnostic value of plasma miR-30a in elderly patients with acute myocardial infarction (AMI). Methods A total of 58 AMI patients and 46 healthy people being chosen in this study from February 2016 to February 2017 in Eighth Hospital and Chinese medicine hospital of Wuhan City in Hubei Province . The expression of circulating miR-30a was detected by RT-qPCR, and ROC curve was drawn to test the diagnostic value of miR-181a. Results Serum miR-30a is significantly elevated in elderly AMI patients compared to healthy elders [(0.08±0.04)vs.(0.16±0.06)], P<0.05. There were positively correlations between the expression of circulating miR-30a in AMI with CK-MB (r=0.721, P<0.05) and cTnI(r=0.698, P<0.05). In addition, the diagnostic sensitively and specialty of miR-30a was 84.2% and 69.6%, respectively. Conclusion MiR-30a is highly expressed in serum of elderly patients with acute myocardial infarction and has certain diagnostic value in elderly patients with acute myocardial infarction.
      作者: 张驰 [1] 韩梅 [1] 夏鹏飞 [2] 王子明 [2]
      Author: Zhang Chi [1] Han Mei [1] Xia Pengfei [2] Wang Ziming [2]
      作者单位: 湖北武汉市第八医院心内科, 武汉,430010 湖北武汉市中医院心内科, 武汉,430010
      年,卷(期): 2018, 10(4)
      分类号: R542.22
      在线出版日期: 2018年6月15日