学术论文

      银杏蜜环口服溶液治疗急性缺血性脑卒中及对血流变和神经功能影响观察

      Observation of Yinxing Mihuan oral solution for acute ischemic stroke and its impacts on hemorheology and neurologic function

      摘要:
      目的 探讨银杏蜜环口服溶液治疗急性缺血性脑卒中的疗效.方法 98例患者随机分为对照组和观察组各49例,对照组予常规治疗,观察组加用银杏蜜环口服溶液,进行美国国立卫生院卒中量表(NIHSS)评分,测定血液流变学指标和神经元特异性烯醇化酶(NSE)、S100B蛋白、同型半胱氨酸(Hcy)、神经肽Y(NPY)和一氧化氮(NO)含量,记录不良反应和死亡率.结果 治疗后,两组血流变指标、神经功能相关因子NSE、S100B、Hcy、NPY和NO均降低(P<0.05);组间相比,观察组全血黏度、血浆黏度、NSE、S100B、Hcy明显降低(P<0.05).其余指标相近(P>0.05).结论 银杏蜜环口服溶液可明显改善急性缺血性脑卒中患者神经功能,值得临床推广应用.
      Abstract:
      To observe the clinical effects of Yinxing Mihuan oral solution for acute ischemic stroke. Methods 98 patients with acute ischemic stroke were randomly divided into control group (49 cases) and study group (49 cases). The control group received conventional treatments, the study group received Yinxing Mihuan oral solution additionally. The National Institutes of Health Stroke Scale (NIHSS), the hemorheology indexes, the serum levels of NSE, S100B, Hcy, NPY, NO were determined. the adverse reactions and mortality were recorded. Results After treatment, the hemorheology indexes, the serum levels of NSE, S100B, Hcy, NPY, NO decreased in both groups (P<0.05). Compared with those in control group, the whole blood viscosity, plasma viscosity, NSE, S100B and Hcy decreased greatly in study group (P<0.05). The other indexes were similar (P>0.05). Conclusion Yinxing Mihuan oral solution could improve neurologic function for acute ischemic stroke patients, and it is worthy of wide clinical use.
      Author: Cheng Weining Tan Dengyun Huang Rong Sony Yuxi Li Xiaolin
      作者单位: 武汉市新洲区人民医院神经内科, 武汉,430060
      年,卷(期): 2019, 11(6)
      分类号: R743.3
      在线出版日期: 2019年7月25日
      基金项目: 武汉市卫计委科研基金资助项目